Pregnant women who eat low-fat yoghurt can increase the risk of their child developing asthma and hay fever, a study says. At the European Respiratory Society conference, researchers will suggest this could be due to an absence of protective fatty acids in yoghurt.
Category Archives: News
We all know that too much inactivity is bad for us, but according to a recent study by The Journal of the American College of Cardiology it could be even worse than we thought.
I’ve long thought that just Gluten may be causing damage in everyone, it’s just that in many case the damage may be below the level that can be detected clinically. Until of course it’s too late. This new study published in the Scandinavian Journal of Gastroenterology would seem to agree.
Objective. Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release and signaling. Material and methods. Both ex vivo human small intestines and intestinal cell monolayers were exposed to gliadin, and zonulin release and changes in paracellular permeability were monitored in the presence and absence of zonulin antagonism. Zonulin binding, cytoskeletal rearrangement, and zonula occludens-1 (ZO-1) redistribution were evaluated by immunofluorescence microscopy. Tight junction occludin and ZO-1 gene expression was evaluated by real-time polymerase chain reaction (PCR). Results. When exposed to gliadin, zonulin receptor-positive IEC6 and Caco2 cells released zonulin in the cell medium with subsequent zonulin binding to the cell surface, rearrangement of the cell cytoskeleton, loss of occludin-ZO1 protein–protein interaction, and increased monolayer permeability. Pretreatment with the zonulin antagonist FZI/0 blocked these changes without affecting zonulin release. When exposed to luminal gliadin, intestinal biopsies from celiac patients in remission expressed a sustained luminal zonulin release and increase in intestinal permeability that was blocked by FZI/0 pretreatment. Conversely, biopsies from non-celiac patients demonstrated a limited, transient zonulin release which was paralleled by an increase in intestinal permeability that never reached the level of permeability seen in celiac disease (CD) tissues. Chronic gliadin exposure caused down-regulation of both ZO-1 and occludin gene expression. Conclusions. Based on our results, we concluded that gliadin activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.
High levels of the stress hormone cortisol are closely linked to death from cardiovascular disease, a Dutch study suggests. In a six-year study of 860 over-65s, those with the highest levels of cortisol had a five-fold risk of death from cardiovascular disease.
Interesting article in Time today…
Paddon-Jones presented some interesting new data from his lab on the effect of eating protein on muscle-building in both young and elderly study subjects. He reported that contrary to conventional wisdom, which holds that the elderly tend to lose their ability to make muscle from the protein they eat, rates of muscle building remains the same throughout life – as little as 4 oz of lean beef or chicken (which contains about 30g of protein) can boost muscle bulk by 50%.
Fabio Capello needs a history lesson. The retired Italian footballer and current manager of England’s seeded – and now soundly defeated – World Cup team banned butter as part of the team’s rigorous training regimen.
Can you even remember what it used to be like, to go out for the evening and be surrounded by smokers? For me the fact that it just seems like a lifetime ago when we used to be forced to work and socialse in the midst of secondary smoke. Anyway, here’s why they’ll never bring smoking in public back.
The number of heart attacks has fallen dramatically since the smoking ban came in, figures reveal.
At least 1,200 heart attacks were prevented in England in the year after the ban’s introduction, according to a report in the British Medical Journal.
In the largest study of its kind, information on adult heart attack patients from the five years before the ban came into force in July 2007, was compared with data from the subsequent 14 months.